Cocrysta® Silybin

A super-bioavailable flavonoid that supports liver health, promotes detoxification, and enhances overall wellness by protecting cells from oxidative stress.

Patent protected
High silybin content (≥60%)
100 times higher solubility
16 times higher absorption
Lower dosage are recommended

Benefits
Why Cocrysta®
What Cocrysta® does
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Benefits

Silymarin, extracted from the seeds of milk thistle, is a complex mixture of flavonolignans and flavonoid polyphenolic compounds. The main silymarin flavonolignans are silybin, isosilybin, silydianin, and silychristin, among which only silybin stands out as a key active ingredient.

Antioxidant Activity
Anti-fibrotic Effect
Detoxification Support
Hepatoprotection Effect

Why Cocrysta®

While silybin is known for its impressive health benefits, its clinical efficacy has been hindered by poor water solubility (<0.04 mg/ml) and low bioavailability (<1%).

With Cocrysta® Silybin, we’ve harnessed innovative cocrystallization technology to revolutionize the way you experience silybin. Our advanced formula offers significantly improved solubility and delivers an outstanding 16 times higher bioavailability. As a result, the same clinical efficacy can be achieved with lower dosages.

Superior Stability

Experimental Conditions: 40 °C, 75% relative humidity (RH), double-layer PE packaging.
Results: Compared with the silybin–phospholipid complex (melting point: 35 °C), Cocrysta® Silybin has a significantly higher melting point (203 °C), indicating superior thermal and oxidative stability.
Improved Dissolution Profile

Conditions: 37 °C; pH 2.0, 4.5, and 6.8 aqueous media with 0.5% PVP.
Results: The solubility of Cocrysta® Silybin was 77-fold, 100-fold, and 50-fold higher than silybin extract in the respective media.
Enhanced Bioavailability

Animals: 18 male SD rats were divided into 3 groups, with 6 rats in each group.
Dose: 50 mg/kg (equivalent to Silybin)
Results: The biovailability of Cocrysta® Silybin is increased by 16.0 times and 2.5 times compared with traditional silybin extract and silybin-phospholipid complex, respectively.