Cocrysta® Rutin

A completely water-soluble and super-bioavailable flavonoid that supports cardiovascular health, enhances circulation, and provides antioxidant protection.

Patent protected
20 times higher solubility
5 times higher absorption
Efficacy proven by peer-review publication

Benefits
Why Cocrysta®
What Cocrysta® does
Guidelines
Patents
More to Share

Benefits

Rutin, also known as Vitamin P, is a natural flavonoid glycoside widely present in various plants, including buckwheat, citrus fruits, and asparagus. With its potential to boost immunity and reduce oxidative stress, rutin is a valuable ingredient in nutraceutical and cosmetic applications.

Antioxidant Activity
Cardiovascular Protection
Anti-inflammatory Effects
Anti-aging
Blood Glucose Regulation

Why Cocrysta®

Traditional rutin products have poor water solubility (0.1 mg/mL), resulting in a bioavailability of only 4.9%. The extremely limited solubility restricts their use in pharmaceuticals, dietary supplements and cosmetics.

Cocrysta® rutin is a cocrystal created from rutin and an edible coformer. Compared to rutin from other sources, Cocrysta® rutin offers approximately 20 times greater water solubility and 5 times higher oral bioavailability.

Improved Solubility

Conditions: 37 °C; pH 2.0, 4.5, and 6.8 aqueous media.
Results: The solubility of Cocrysta® Rutin was approximately 20 times higher than conventional rutin.
Enhanced Bioavailability

Animals:14 male SD rats, divided into 2 groups (n=7).
Dosage: 105 mg/kg (equivalent to rutin)
Results: The Cocrysta® Rutin increased Cmax by 3.8-fold and AUC by 5.6-fold compared with conventional rutin.
Cardioprotective Effect

Animals: 28 male SD rats, divided into 4 groups, with 6 rats in each group.
Dosage: 105 mg/kg (equivalent to rutin)
Results: In an isoproterenol-induced cardiac injury model, Cocrysta® Rutin significantly reduced levels of biomarkers like Creatine kinase (CK), CK-MB isoenzyme, and lactate dehydrogenase (LDH), outperforming conventional rutin.
Clinically Proven Anti-Wrinkle Efficacy (Cosmetics)

Topical application of 2% Cocrysta® Rutin significantly reduced wrinkle length, depth, area, and volume after 28 days. It demonstrated faster and more effective results than rutin alone.
Anti-Diabetic

Design: After fasting, rats received either blank solvent (control), conventional rutin, or Cocrysta® Rutin, followed with 2 g/kg 50% glucose solution. Blood glucose was measured at 0 h, 0.5 h, and 2 h post-glucose.
Animals: 24 male SD rats, divided into 3 groups, with 8 rats in each group.
Dosage: 60 mg/kg (equivalent to rutin)
Results: Cocrysta® Rutin group significantly reduced the glycemic response, showing improved glucose tolerance.