Cocrysta® Ubiquinol

A highly stable and bioavailable antioxidant that supports cellular energy production, promotes overall heart health, and enhances vitality.

Patent protected
Significantly improved stability
38 times higher solubility
3-8 times higher absorption validated by published clinical trials
Suitable for various application forms

Benefits
Why Cocrysta®
What Cocrysta® does
Guidelines
Patents
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Benefits

Coenzyme Q10 (CoQ10) is a vital antioxidant present in every cell of the human body. The versatile benefits of CoQ10 have been supported by extensive clinical studies.

Cardiovascular Health
Energy Boost
Reproductive Health
Immune Support

How CoQ10 works

CoQ10 plays a crucial role in the mitochondrial electron transport chain, where it facilitates the production of energy by promoting oxidative phosphorylation.

This process helps generate ATP, the primary energy carrier in cells, which is essential for various cellular functions.

Ubiquinol vs. Ubiquinone

CoQ10 exists in two forms in the human body: the oxidized form (ubiquinone) and the reduced form (ubiquinol). In blood circulation, ~95% of CoQ10 is present in the ubiquinol form.

While ubiquinone needs to be reduced into ubiquinol before it can be absorbed, ubiquinol can be directly absorbed by human body, leading to higher bioavailability.

Why Cocrysta®

Ubiquinol is sensitive to oxygen and heat, leading to poor stability that causes over 70% degradation at room temperature in just one month. Despite its higher bioavailability, the poor stability significantly limits its use in dietary supplements.

Cocrysta® Ubiquinol provide revolutionary solution to the common stability issues associated with traditional ubiquinol. It offers a superior stability and a higher melting point, making it suitable for versatile dosage forms. Moreover, it delivers enhanced solubility and 5 times greater bioavailability, ensuring the maximum benefits for health.

Improved Stability

After 28 days in open condition, Cocrysta® Ubiquinol maintains >95% content, while only <30% are left in conventional ubiquinol.

Cocrysta® Ubiquinol also demonstrates superior thermal stability with a significantly higher melting point compared with conventional ubiquinol.
Higher Solubility

Cocrysta® Ubiquinol features superior dissolution performance. In 3 hours, Cocrysta® Ubiquinol shows an impressive 38 times and a 28 times higher solubility in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF), respectively.
Enhanced Bioavailability-Animal Study

Animals: 12 male SD rats are divided into two groups, with 6 rats in each group.
Dose: 100 mg/kg (equivalent to Ubiquinol)
Results: Compared with Ubiquinone, Cocrysta® Ubiquinol displays higher absorption, with 4.3 times higher Cmax and 4.5 times higher AUC0-24.
Enhanced Bioavailability-Human Study

Subject: 12 healthy subjects（Age: 45-65，BMI: 18.5-30 kg/㎡）
Design: Randomized, Double-blinded, Cross-over.
Dosage: 240 mg
Test Product: J* ® Ubiquinol softgel（Using Cocrysta® Ubiquinol）
Reference Product: J* ® Ubiquinone softgel
Results: Compared to Ubiquinone group, Cocrysta® Ubiquinol group shows 2.2X and 2.0X increase in mean Cmax and AUC, respectively.

Guidelines

Dosage Forms
Guidelines:
Do not mix with citric acid, malic acid, or minerals, e.g., zinc, copper, and manganese, to avoid oxidation of ubiquinol.
Recommended Dosage: 100-120 mg/day Cocrysta® Ubiquinol