Cocrysta® Hydroxytyrosol

A powerful antioxidant found in olives that supports heart health, promotes healthy aging, and provides protection against oxidative stress.

Patent protected
Stable white powder with low hygroscopicity
Soluble both in water
Efficacy proven by peer-review publications

Benefits
Why Cocrysta®
What Cocrysta® does
Guidelines
Patents
More to Share

Benefits

Hydroxytyrosol is a bioactive component in olives. It is considered to be one of the most effective antioxidants. With an antioxidant capacity over 10 times greater than vitamin C, it offers numerous health benefits.

Cardiovascular Health
Cognitive Health
Joint Health
Skin whitening

Why Cocrysta®

Traditional hydroxytyrosol has a low melting point and is highly hygroscopic, which means it easily absorbs moisture from the air and turns into a sticky syrup with poor stability.

With Cocrysta® Hydroxytyrosol, we’ve harnessed advanced cocrystallization technology to create a crystalline powder that contains 53% hydroxytyrosol. This powerful formula boasts low hygroscopicity and exceptional physicochemical stability, ensuring that you get the most out of your supplement.

Plus, it offers superior powder flowability and processability, making it easier to incorporate into a variety of applications.

Higher Melting Point & Lower Hygroscopicity

The Cocrysta® Hydroxytyrosol has a melting point of 112 °C, contributing to its chemical stability.

Compared with encapsulated powders and crude extracts (moisture uptake >12% at 75% RH), the Cocrysta® Hydroxytyrosol absorbed less than 0.5% moisture.
LDL-lowering Effect

Animal groups：
HFD: High fat diet group
Crystal HT: High fat diet + 7.5 mg/kg Cocrysta® HT，28 days.
SL: High fat diet + 50 mg/kg Soybean Lecithin，28 days.
FO: High fat diet + 210 mg/kg Fish oil (22%DHA+33%EPA)，28 day.
Results：Cocrysta® HT at a dosage of 7.5 mg/kg reduces both triglyceride level and LDL level, which demonstrates comparable efficacy to 210 mg/kg fish oil.
Capsule Stability

Marketed capsule products using conventional hydroxytyrosol experienced severe clumping and discoloration under accelerated condition, while Cocrysta® HT capsules maintained physical integrity and color stability.
Skin Whitening

Design：
Sample area: 2% Crystal HT® serum
Negative control area:Blackened area blank control
Positive control area: 7% ascorbic acid (Vitamin C) serum
Subjects: 36 individuals
Results: The Clinical study indicated that 2% Cocrysta® HT formulations deliver a superior skin-lightening effect compared to 7% Vitamin C-based products.

Guidelines

Dosage Forms
Guidelines
For solid forms: Avoid combination with strong acidic ingredients (e.g., α-ketoglutaric acid).
For liquid forms: Recommended pH < 5.
Recommended Dosage: 20-50 mg/day Cocrysta® Hydroxytyrosol